I would, Tennessee will throw it all over Houston horrible secondary. Donald Driver didn't do much the first game, so why not.
Edit: For the defense player, I am not sure who is available, but I would look at the fantasy stats from previous years to see who produces the most points and pick him up.
Would you start Calvin Johnson or Donald Driver in week 4 of fantasy football?
Calvin Johnson. Driver against the Vikings is a really bad matchup. the bears secondary is their weakest link so Calvin Johnson will be a go to guy especially if Detroit is down or its a back and forth game.